Quentin went 3-for-4, with all of his hits coming in the first four innings of Chicago's 15-10 triumph.
After Paul Konerko opened the scoring in the top of the first inning with an RBI single, Quentin followed with the same, then smacked a two-run homer in the 3rd, and doubled in two more in Chicago's 8-run 4th, putting the Sox up, 14-0.
Mark Beuhrle allowed four runs over six innings, and the Chicago bullpen gave up another six runs, but it still wasn't enough to catch the White Sox.
In their opening day, 6-3 win over the Cubs, second baseman Neil Walker brought the Pirates back from a 2-run deficit with a grand slam homer in the 4th inning, and scored again after doubling in the 7th, when Andrew McCutchen also homered.
Walker finished his 2011 debut going 2-for-4 with 4 RBI and a pair of runs, getting the Pirates off to a solid start.
Walker showed tremendous potential in 134 games last season for Pittsburgh, batting .290 with 13 homers and 70 RBI.