Minnesota scored seven runs in the 10th inning to take their second straight on the road from the still-struggling Angels.
The scoring outburst was punctuated by rookie catcher Chris Herrmann's grand slam, leading to the 10-3 victory.
The blast was just the second of Herrmann's brief major league career. Herrmann had two singles prior to the slam, going 3-for-5 for the game. He's played in just nine games, but is batting a brisk .409, with nine hits in 22 at-bats.
The Twins will go for the sweep of the Angels Wednesday afternoon at 12:35 pm PDT.
Zack Cozart went 4-for-4 in the opener, a 9-3 win for the Reds, prior to dropping the nightcap, 5-3, an unusual situation due to the game being a make-up, in which the Reds were the home team at San Francisco's AT&T Park.
Cozart got the Reds on the board in the second inning with the first of his four hits, singling home a run and scoring later as Cincinnati plated four runs in the frame. Cozart singled and scored again in the third, belted a solo homer in the fifth and singled again in the seventh to complete his night of plate perfection.
The series wraps up Wednesday night at 7:10 pm PDT in San Francisco.
Today's Trivia: Speaking of Mike Schmidt - a three-time NL MVP, how many times did he lead the NL in home runs? (answer tomorrow)
Yesterday's Answer: Even though Mike Schmidt hit many more homers than Brooks Robinson (548-268), the Baltimore hot-corner Hoover played for 23 years - five more than Schmidt - and amassed 2848 hits, to Schmidt's 2234.