|Jones: 2HR, 4RBI|
Jones cracked a two-run shot in the opening frame and broke a 2-2 tie with another two-run bomb in the sixth, chasing Angels' starter Matt Shoemaker, who took the loss.
The win boosted the Orioles lead to four games in the East, as the Yankees and Blue Jays each lost and remained tied for second.
Batting .300 with 19 homers and 63 RBI, Jones is among AL leaders and makes the O's a threat for October baseball.
Game two of the three-game series commences Tuesday at 10:05 pm PDT.
While the Nats cranked out a cumulative 13 hits, much of the damage at the plate was done by Ian Desmond, who went 5-for-5 with four singles and a two-run homer, giving him 62 RBI on the season.
Desmond also scored three times in his five at-bats.
The Nationals will try to send the Rockies to their seventh straight defeat when game two of the three-game series begins Tuesday at 8:40 pm EDT.